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Mar 06

An Overview of The Short-Term FDA-Approved Weight Loss Drugs

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Although there are a plethora of weight loss drugs on the market, they are however generally classified as being either prescription or non-prescription based. The prescription weight loss drugs, also referred to as ethical drugs, are drugs which have been approved by the FDA and which can only be bought through the approval of a doctor.

Equally, the various FDA approved prescription weight loss drugs can be further classified into two different groups based on their specific duration of use – i.e. being either short- or long-term. This article takes a look at the currently FDA approved short-term weight loss drugs and coincidentally, they all happen to be appetite suppressing medications.

Appetite suppressing medications work by either decreasing appetite or increasing the feeling of fullness. They generally work on the basic idea of controlling the hypothalamus – the appetite control center of the brain – by increasing one or more brain chemicals that modulate mood and appetite.

The approved appetite suppressing drugs belong to a group of drugs known as phenethylamines – somewhat similar to amphetamines. Amphetamines are any of a group of powerful stimulant drugs that act on the central nervous system and which normally causes increase in heart rate, blood pressure, and energy levels. Despite the fact that phenethylamines are chemically similar to amphetamines, they however have a significantly reduced incidence of the side effects associated with amphetamines.

The FDA-approved appetite suppressing medications affect the central nervous system through several different active ingredients and modulation mechanisms. These appetite suppressing medications can be divided into three major active ingredient groups as follows:

Phentermine
These are probably the most widely used short-term prescription-based weight loss drugs today. Phentermine based appetite suppressants were first approved in 1959 and specifically to be used for short-term treatment of obesity, usually not longer than six months.

The main active ingredient used in Phentermine is Phentermine hydrochloride which stimulates a group of neurotransmitters known as catecholamine including epinephrine (also known as adrenaline), norepinephrine, and dopamine. Phentermine hydrochloride affects the central nervous system by triggering a “fight or flight” state in the body.

This condition is generally believed to cause the brain not to receive the hunger signals the stomach might be sending to it because of its concentration on how to respond to the immediate and more serious need for energy caused by the “fight or flight” signal.

Apart from the above effect, Phentermine is also understood to increase the level of leptin – the hunger suppressing hormone which normally creates the feeling of fullness in the body. Furthermore, Phentermine is thought to inhibit the function of the neurotransmitter known as neuropeptide Y which is believed to decrease physical activity levels, encourage fat storage, and increase appetite.

Therefore, Phentermine based appetite suppressing medications have the combined ability of making a person feel satiated thereby inhibiting the feeling of hunger, reducing body fat storage, and also increasing energy levels.<———

However, Phentermines have certain side effects of varying degrees which include constipation, dry mouth, insomnia, blurred vision, irritability, as well as symptoms of withdrawal and addiction.

Phentermine hydrochloride is marketed under a large number of brand names such as Adipex-P, Fastin, Ionamin, Pro-Fast, Teramine, Oby-trim, Anoxine-AM, Phentrol, Obestin-30, and Zantryl amongst others.

Phendimetrazine
Phendimetrazine is a phenylalkylamine sympathomimetic amine which belongs to the phenethylamine group of drugs and was approved by the FDA in 1976. It functions by stimulating the central nervous system but in a stronger way than Phentermine.

Phendimetrazine is available as both an immediate release (regular) capsule that is taken two or three times a day and as an extended release tablet that can be taken once a day. Although it is known to provide users with sustained energy levels throughout the day, it however lacks the appetite suppressing capability of Phentermine.

However, individuals with high blood pressure, glaucoma, heart ailment, and arteriosclerosis are strongly advised against taking Phendimetrazine. Some of the side effects of using Phendimetrazine include constipation, dizziness, headaches, insomnia, and dry mouth and as with Phentermines, they can also become easily addictive.

Phendimetrazine is sold under different brand names including Adipost, Bontril, Plegine, Prelu-2, and X-Trozine.

Diethylpropion
Diethylpropion hydrochloride based appetite suppressing drugs were approved by the FDA in 1959 but are not actually as popular as the others. Diethylpropion is usually prescribed for short-term use of about a few weeks as part of a general weight loss diet.

Diethylpropion stimulates the central nervous system thereby causing an increase in heart rate and blood pressure while also suppressing the appetite. However, the exact mechanism of how Diethylpropion stimulates the central nervous system to result in appetite suppression is not yet fully understood. Some of the side effects associated with using Diethylpropion include irritability, headaches, dizziness, insomnia, dry mouth, and constipation.

Diethylpropion is marketed under the brand name Tenuate and is available as both immediate-release tablets (Tenuate) and controlled-release tablets (Tenuate Dospan).

However, it is important to understand that prescription based weight loss drugs can only be approved for use to individuals who are considered to be either overweight (with a BMI of 27 or above and having an obesity-related condition) or obese (with a BMI of 30 or above and having an obesity-related condition). Some of the obesity-related conditions may include high blood pressure, type II diabetes, or hyperlipidemia – an excessive level of fats such as cholesterol and triglycerides in the blood.

Fortunately for those seeking immediate respite, Phen375, which is also known as Phentemine375, is a new clinically proven and effective pharmaceutical-grade appetite suppressant and fat burner.

Phen375 is manufactured in FDA registered pharmaceutical labs in California and made from high quality active ingredients such as Dimethylpentalyne, Trimethylxanthine, Dehydroepiandrosterone (DHEA), and L-carnitine. The combination of these compounds in Phen375 virtually makes it the MOST POWERFUL non-prescription weight loss supplement available today.

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Article Source: EzineArticles.com/expert/Marcus_J_Michael/1230411